{"id":3343,"date":"2021-05-27T10:45:07","date_gmt":"2021-05-27T14:45:07","guid":{"rendered":"https:\/\/www.kemitek.org\/?post_type=portfolio&#038;p=3343&#038;lang=en"},"modified":"2021-05-27T12:10:55","modified_gmt":"2021-05-27T16:10:55","slug":"subcp","status":"publish","type":"portfolio","link":"https:\/\/www.kemitek.org\/en\/portfolio-item\/subcp\/","title":{"rendered":"Industrial Biotechnology, Jun 2019, 157-161"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-cdae15e34a672b3b9cdbd528e24f64bd\">\n#top .av-special-heading.av-av_heading-cdae15e34a672b3b9cdbd528e24f64bd{\npadding-bottom:20px;\nfont-size:70px;\n}\n.av-special-heading.av-av_heading-cdae15e34a672b3b9cdbd528e24f64bd .av-subheading{\nfont-size:30px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-cdae15e34a672b3b9cdbd528e24f64bd av-special-heading-h1 blockquote modern-quote  avia-builder-el-0  el_before_av_one_third  avia-builder-el-first  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Scaling Up Biotechnological Chemical Processes<\/h1><div class='av-subheading av-subheading_below '><p>Article published in Industrial Biotechnology, Jun 2019, 157-161<br \/>\nDOI: 10.1089\/ind.2019.29173.eef<\/p>\n<\/div><div class='special-heading-border'><div class='special-heading-inner-border'><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_third-93407bb19249d2c06b1ab9d23b9661df\">\n#top .flex_column.av-av_one_third-93407bb19249d2c06b1ab9d23b9661df{\nmargin-top:0px;\nmargin-bottom:0px;\n}\n.flex_column.av-av_one_third-93407bb19249d2c06b1ab9d23b9661df{\nborder-radius:0px 0px 0px 0px;\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\n}\n.responsive #top #wrap_all .flex_column.av-av_one_third-93407bb19249d2c06b1ab9d23b9661df{\nmargin-top:0px;\nmargin-bottom:0px;\n}\n<\/style>\n<div class='flex_column 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class='wp-image-3967 avia-img-lazy-loading-not-3967 avia_image' src=\"https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1.png\" alt='' title='SUBCP'  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1.png 933w, https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1-232x300.png 232w, https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1-768x991.png 768w, https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1-798x1030.png 798w, https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1-546x705.png 546w, https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/SUBCP-1-450x581.png 450w\" sizes=\"(max-width: 933px) 100vw, 933px\" \/><\/a><\/div><\/div><\/div><br \/>\n<div  class='avia-button-wrap avia-button-center  avia-builder-el-3  el_after_av_image  avia-builder-el-last ' ><a href='https:\/\/www.kemitek.org\/wp-content\/uploads\/2021\/05\/ind.2019.29173.eef_.pdf' class='avia-button av-av_button-91f0a059826c89dba5342172ee6c9274 avia-icon_select-yes-left-icon avia-size-medium avia-position-center avia-color-theme-color ' target=\"_blank\" rel=\"noopener noreferrer\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue84c' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >T\u00e9l\u00e9chargez<\/span><\/a><\/div><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_third-531d5d4d3d3a74d4c56d8363993d8877\">\n#top .flex_column.av-av_two_third-531d5d4d3d3a74d4c56d8363993d8877{\nmargin-top:0px;\nmargin-bottom:0px;\n}\n.flex_column.av-av_two_third-531d5d4d3d3a74d4c56d8363993d8877{\nborder-radius:0px 0px 0px 0px;\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\n}\n.responsive #top #wrap_all .flex_column.av-av_two_third-531d5d4d3d3a74d4c56d8363993d8877{\nmargin-top:0px;\nmargin-bottom:0px;\n}\n<\/style>\n<div class='flex_column av-av_two_third-531d5d4d3d3a74d4c56d8363993d8877 av_two_third  avia-builder-el-4  el_after_av_one_third  avia-builder-el-last  flex_column_div av-zero-column-padding '   ><section  class='av_textblock_section av-av_textblock-0366cc7376be6c9e82a3e9cc8987b64f '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock '  itemprop=\"text\" ><h3>Scaling Up Biotechnological Chemical Processes: A Better Alternative to the Traditional Develop-Then-Scale Model<\/h3>\n<h3>ABSTRACT<\/h3>\n<p>Industrial biotechnologies often rely on chemistry that is developed in the lab. The typical timeline of a biotechnological innovation, much like other chemical innovation typically looks like Fig. 1. Unfortunately, many biotechnologies that look promising after their initial laboratory development fail to cross the barrier to industrial scale, or do so at conditions that do not make economic sense. Process scaling is an art form that requires forethought, time, and experience. A thoroughly conducted scale-up phase is essential to the long-term success of a factory process. Unfortunately, it is a step that is too often neglected by developers of new technologies and project promoters alike as they underestimate the complexity, time, and expertise needed in the fast-moving world of business development. The pilot or scaling-up phase is often seen as a metaphorical roadblock to be overcome as fast as possible on the road to production and sales, rather than a very necessary and worthwhile step to ensure long-term viability, safety, and performance of the process. Putting more emphasis on this step would save time and money and give a better understanding of the safest ways to control the process. To have a successful scaling-up process, collaboration between laboratory scientists and process engineers is crucial. It is also necessary to prepare the migration of a process from lab to plant scale not once you\u2019re ready to do said scale-up, but right from the conception of the synthesis at the lab scale. It will be important to evaluate and analyze the parameters which, on a small scale, seem irrelevant but become very important and greatly influence the process on a large scale. 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